Department of Surgery
School of Medicine Queen's University
 

Research Staff



Dr Susan Brogly


Dr Susan Brogly
University Position:
Assistant Professor

Areas of Research Interest: 
Perinatal epidemiology, pediatrics, epidemiologic methods, bias analyses simulation, infectious diseases, surgical outcomes

Contact Information:
Kingston General Hospital
Watkins C, 5-4-321
Kingston, Ontario K7L 3Y7
613-549-6666 x8227
Email: susan.brogly@queensu.ca




Dr. Susan Brogly joined Queen’s Department of Surgery in 2014 after spending 12 years in Boston where she was a faculty member of Epidemiology at Boston University (2009-2014) and a research faculty member at the Center for Biostatistics in AIDS Research at Harvard University (2002-2009).  Dr. Brogly has been leading an epidemiology research program on surgical outcomes since joining the Department of Surgery.  Dr. Brogly is Principal Investigator of a study of the comparative safety of buprenorphine vs. methadone in pregnancy funded by the US National Institute of Child Health and Human Development and has been awarded funds from the American Cancer Society, the Queen’s Principal Senate Advisory Research Committee and other organizations.  Dr. Brogly is a Queen’s ICES Fellow and hold adjunct appointments in Queen’s Public Health Sciences and the Department of Epidemiology at the Boston University School of Public Health.  She teaches in Queen’s Public Health Sciences and the Department of Epidemiology at Boston University, and is currently the primary thesis supervisor of two M.Sc. students.  Dr. Brogly received her Ph.D. and M.Sc. in epidemiology from McGill University, and a B.Sc. in chemical engineering from Queen’s University

Publications: Dr. Brogly’s publications are available on PubMed https://www.ncbi.nlm.nih.gov/pubmed/?term=brogly+s

Click here to read Dr. Brogly's article in the Queen's Gazette April 10, 2017 entitled
"Addressing Addictions" Study reveals some women with prenatal opioid dependence are not being treated.



Dr Mark Ormiston

Mark OrmistonUniversity Position:
Assistant Professor

Contact Information:
Botterell Hall A209,
B
iomedical And Molecular Sciences
Kingston, ON
K7L 3N6
Telephone: 613-533-6241

Email: mark.ormiston@queensu.ca

Research Interests:
My research is centered on the cellular mechanisms governing vascular remodeling in health and disease, with a particular focus on the capacity of circulating cells of the immune system to regulate blood vessel integrity, growth and repair. This interest is rooted in my study of pulmonary arterial hypertension (PAH), a disease of pathological vascular remodeling and right heart failure that is linked to immune dysfunction. PAH is strongly associated with loss-of-function mutations in the bone morphogenetic protein  (BMP) type II receptor (BMPR-II), a receptor of the transforming growth factor-β (TGFβ) superfamily. Identification of this link between PAH and BMPR-II haploinsufficiency has provided considerable insight into the mechanisms governing pulmonary vascular homeostasis and makes PAH an ideal candidate for proof-of-concept regenerative and cell-based therapeutic strategies.

 

More specifically, I am interested in the capacity of innate lymphocytes, such as Natural Killer (NK) cells, to influence vascular growth and repair. Beyond their traditional role as the cytotoxic effector cells of innate immunity, there is a growing body of literature supporting a role for NK cells in the regulation of vascular remodelling, particularly in pregnancy. My previous work has identified a phenotypic and functional defect in the circulating NK cells of PAH patients, associated with increased TGFβ signalling and elevated production of matrix metalloproteinase (MMP)-9 by these cells. Through my ongoing studies, I aim to (i) determine the mechanisms by which NK cells influence pulmonary vascular homeostasis in health and disease and (ii) clarify the impact of BMPR-II mutations on these processes.


Manuela Kunz

Title:
First recipient of the Fellowship in Surgical Education

Contact Information:
Human Mobility Research Centre
Kingston, ON Kingston General Hospital
K7M 1L2, Canada Kingston, ON K7L 2V7, Canada
Phone: 613-549 6666 ext.7308

Email: kunz@queensu.ca

Postdoctoral Research:
• Computer-Assisted Hip Surgery
• Computer-Assisted Fracture Management
• Image-guided Planning for Total Ankle Arthroplasty

Doctoral Research:
• Development of advanced visualization techniques for image-free computer-assisted Anterior Cruciate Ligament Reconstruction
• Novel applications for kinematic reconstructionin Total Knee Arthroplasties
• Development and testing of an intra-operative tracking system for patella movement
• Application for fluoroscopy guided cartilage repair surgery
• Application of Virtual Reality techniques in computer-assisted surgeries for improved man-made interfaces
• Development of application for endoscopy based surgical navigation
• Investigation of surgical navigation for shoulder surgeries

Masters Research:
• High level, multi colored Petri Nets: High Level Petri Nets are used for simulation of complex parallel algorithms. In my thesis, I investigated the relationship between structural properties of these nets and behavior of the simulated algorithm