Kingston General Hospital
Watkins C, 5-4-321
Kingston, Ontario K7L 3Y7
Dr. Susan Brogly is an epidemiologist whose research interests include perinatal epidemiology, addiction, surgical outcomes, and the application of innovative methodologies in medical studies. Dr. Brogly has published over 40 scientific articles, served on grant review boards for the Canadian Institutes of Health Research, the Centers for Disease Control, and the March of Dimes, and is a recipient of the Boston University School of Public Health Excellence in Teaching Award and the Randall Coates New Investigator Memorial Award. Dr. Brogly’s research has been supported with grants from the US National Institute of Child Health and Human Development, the American Cancer Society, Queen’s University, and other organizations. Dr. Brogly joined Queen’s Department of Surgery in 2014 after spending 12 years in Boston where she held appointments as a faculty member of the Department of Epidemiology at the Boston University School of Public Health (2009-2014) and a research faculty member at the Center for Biostatistics in AIDS Research at the Harvard School of Public Health (2002-2009). Dr. Brogly teaches in Queen’s Public Health Sciences Department and the Department of Epidemiology at the Boston University School of Public Health. Dr. Brogly received her Ph.D. and M.Sc. in epidemiology from McGill University, and a B.Sc. in chemical engineering from Queen’s University.
Publications: Dr. Brogly’s publications are available on PubMed https://www.ncbi.nlm.nih.gov/pubmed/?term=brogly+s
Click here to read Dr. Brogly's article in the Queen's Gazette April 10, 2017 entitled
"Addressing Addictions" Study reveals some women with prenatal opioid dependence are not being treated.
Dr Mark Ormiston
Botterell Hall A209,
Biomedical And Molecular Sciences
My research is centered on the cellular mechanisms governing vascular remodeling in health and disease, with a particular focus on the capacity of circulating cells of the immune system to regulate blood vessel integrity, growth and repair. This interest is rooted in my study of pulmonary arterial hypertension (PAH), a disease of pathological vascular remodeling and right heart failure that is linked to immune dysfunction. PAH is strongly associated with loss-of-function mutations in the bone morphogenetic protein (BMP) type II receptor (BMPR-II), a receptor of the transforming growth factor-β (TGFβ) superfamily. Identification of this link between PAH and BMPR-II haploinsufficiency has provided considerable insight into the mechanisms governing pulmonary vascular homeostasis and makes PAH an ideal candidate for proof-of-concept regenerative and cell-based therapeutic strategies.
More specifically, I am interested in the capacity of innate lymphocytes, such as Natural Killer (NK) cells, to influence vascular growth and repair. Beyond their traditional role as the cytotoxic effector cells of innate immunity, there is a growing body of literature supporting a role for NK cells in the regulation of vascular remodelling, particularly in pregnancy. My previous work has identified a phenotypic and functional defect in the circulating NK cells of PAH patients, associated with increased TGFβ signalling and elevated production of matrix metalloproteinase (MMP)-9 by these cells. Through my ongoing studies, I aim to (i) determine the mechanisms by which NK cells influence pulmonary vascular homeostasis in health and disease and (ii) clarify the impact of BMPR-II mutations on these processes.
First recipient of the Fellowship in Surgical Education
Human Mobility Research Centre
Kingston, ON Kingston General Hospital
K7M 1L2, Canada Kingston, ON K7L 2V7, Canada
Phone: 613-549 6666 ext.7308
• Computer-Assisted Hip Surgery
• Computer-Assisted Fracture Management
• Image-guided Planning for Total Ankle Arthroplasty
• Development of advanced visualization techniques for image-free computer-assisted Anterior Cruciate Ligament Reconstruction
• Novel applications for kinematic reconstructionin Total Knee Arthroplasties
• Development and testing of an intra-operative tracking system for patella movement
• Application for fluoroscopy guided cartilage repair surgery
• Application of Virtual Reality techniques in computer-assisted surgeries for improved man-made interfaces
• Development of application for endoscopy based surgical navigation
• Investigation of surgical navigation for shoulder surgeries
• High level, multi colored Petri Nets: High Level Petri Nets are used for simulation of complex parallel algorithms. In my thesis, I investigated the relationship between structural properties of these nets and behavior of the simulated algorithm