Department of Surgery
School of Medicine Queen's University
 

Dr Sulaiman Nanji

Dr Sulaiman Nanji, General Surgeon, Department of Surgery, Queen's University, Kingston General Hospital
University Position:
Assistant Professor

Current Appointments:
Attending Staff, Hotel Dieu Hospital
Attending Staff, Kingston General Hospital

Areas of Clinical Interest:

Liver, Pancreas & Biliary Tract Cancers/Diseases

Areas of Research Interest:
Genetic research in hepatocellular carcinoma and clinical outcomes in hepato-pancreaticobiliary malignancies


Contact Information:

Burr 2 Room 078
Kingston General Hospital
76 Stuart Street
Kingston, ON
K7L 2V7
Ph (613) 549-6666 x4159
Fax (613) 548-2456

Click here to email Dr Nanji


Fellowship:
• 2007-2009, Clinical Fellow, Multi-Organ Transplantation and Hepatobiliary/Pancreatic Surgery, University of Toronto, Toronto, Ontario

Residency:
• 1999-2007, University of Alberta, Edmonton, Alberta

Medical School Graduation:
• 1995-1999, University of British Columbia, Vancouver, British Columbia 

Professional Memberships:
• 2008-present, American Society of Transplant Surgeons
• 2008-present, American Hepato-Pancreato-Biliary Association
• 2004-present, Canadian Society for Clinical Investigation
• 2003-present, Canadian Society for Transplantation
• 2003-present, Canadian Medical Association
• 2002-present, Canadian Association of General Surgeons
• 2001-present, Royal College of Physicians and Surgeons of Canada
• 2003-2006, Aerospace Medical Association

Certifications and Licensure:
• 2007, College of Physicians and Surgeons of Ontario
• 2007, Fellow, Royal College of Physicians and Surgeons of Canada
• 2007, Clinical Investigator, Royal College of Physicians and Surgeons of Canada
• 2002, American College of Surgeons Advanced Trauma Life Support Instructor
• 2001, Licentiate of the Medical Council of Canada (LMCC)

Scholarships and Awards:

Research

2005     University of Alberta, General Surgery Resident Research Day Second Prize Award  
2004     Canadian Society for Clinical Investigation Resident Research Prize  
2004     Canadian Association of General Surgeons Basic Science Award  
2004     University of Alberta, George R Graham Postgraduate Memorial Bursary in Surgery  
2004     University of Alberta, Postgraduate Medical Publication Prize  
2004

    University of Alberta, Department of Surgery Resident Research Second Prize Award  
2004     Canadian Society of Transplantation Young Investigator Award  
2004     Genzyme Canada Fellows Award for Transplantation  
2003     Canadian Association of General Surgeons Basic Science Award  
2003

    University of Alberta, Department of Surgery Resident Research Day Second Prize Award  
2003     University of Alberta, General Surgery Resident Research Day First Prize Award  
2002     Canadian Society for Clinical Investigation Poster Competition Award  
2002     Canadian Association of General Surgeons Basic Science Award  
2002     University of Alberta, General Surgery Resident Research Day Third Prize Award  


Academic

2003 University of Alberta, Honorary Sir Izaak Walton Killam Memorial Scholarship    
2002-2003 Canadian Association of General Surgeons Research Grant Award    
2001-2004 The Canadian Institutes of Health Research Postdoctoral Fellowship Award    
2001-2003

The Alberta Heritage Foundation for Medical Research Clinical Fellowship Award    
1997 Samuel Diamond UBC Faculty of Medicine Scholarship    
1996 Louis Lipsey Toohill UBC Faculty of Medicine Scholarship    
1996 Medical Research Council Summer Studentship Award for Surgical Research    
1990 Premier's Excellence Award for Community and Scholastic Achievement    
1990 Provincial Scholarship Award    
1990 Canada Scholarship Award    
1990 Aga Khan Award for Scholastic Achievement    
1990 Surrey, White Rock Scholarship for Academic Achievement    
1990 Sir William Macdonald Entrance Scholarship to McGill University    
1990 Royal Canadian Geographical Society Award for Outstanding Research    
1990 Gordon M. Shrum Entrance Scholarship to Simon Fraser University for Exceptional Academic Promise    


Other

2004 Canadian Space Agency Aerospace Medicine Award
1990 Terry Fox Humanitarian Award
1990 David Welch Memorial Award from the Kiwanis Association for Outstanding Humanitarianism
1990 Josten's Foundation Award for Excellence in Leadership
1988-1994 Duke of Edinburgh's Bronze, Silver and Gold Awards


University/Administrative Services:

2001-present

Medical Student/Resident Teaching, University of Alberta and University of Toronto
2006-2008

Canadian Association of General Surgeons (CAGS) Hepatobiliary Oncology and Transplantation Committee Member
2001-2006

University of Alberta, Faculty of Medicine and Department of Surgery Selection Committee Member
2004-2005 University of Alberta, Department of Surgery Resident Training Committee
2004-2005 University of Alberta, Department of Surgery Research Committee
2001-2005 University of Alberta, Division of General Surgery Journal Club
1996-1999 University of British Columbia Faculty of Medicine Activities
1995-1997 University of British Columbia Health Outreach Peer Education Program (HOPE)
1994-1995 McGill University Health Services Peer Education Program


Research Training and Experience:

2007-present





Liver resection for colorectal cancer metastases
Toronto General Hospital, Toronto, ON
Supervisor: Dr Steven Gallinger
Project: Evaluation of clinical outcomes in hepatic resection for CRC metastases as well as the effect of chemotherapy associated liver injury

April 2004





National Aeronautics and Space Administration (NASA) and Canadian Space Agency (CSA) Aerospace Medicine Elective
Johnson Space Center, Houston, Texas
Project: Enhance the understanding of medical and surgical challenges during long duration spaceflight (e.g. lunar or Mars missions) with an emphasis on changes in immune function

2001-2004





Tolerance Induction in Experimental Islet Transplantation - PhD Dissertation
Supervisor: Dr AM James Shapiro
Project: Development of clinically translatable strategies for tolerance induction in patients undergoing islet transplantation

2001-2003








Health Related Quality of Life in Islet Transplantation
Department of Public Health Sciences & Institute of Health Economics, Edmonton, Alberta
Supervisor: Dr JA Johnson
Project: Evaluation of quality of care and clinical effectiveness of islet transplantation through the longitudinal assessment of quality of life in islet transplant patients, as compared to type 1 diabetic patients and pancreas transplant patients

July-Aug 2003





University of Texas Medical Branch Aerospace Medicine Summer Studentship
Galveston, Texas & Johnson Space Center, Houston, Texas
Supervisor: Dr J Jernigan & Dr R Jennings
Project: Understanding alternations in human immune function in space

July-Sept 2002




Visiting Scholar to Emory University
Department of Biology and Transplantation Research, Emory University, Atlanta, Georgia
Project: Novel approaches to transplantation tolerance involving the induction of mixed chimerism in small and large animal models

1997-1999






Clinical Research in General Surgery
Department of Surgery, University of British Columbia, Vancouver, British Columbia
Supervisor: Dr DB Allardyce
Project: Antibiotics and emergence of Clostridium difficile colitis in surgical patients

1996-1997






Clinical Research in Vascular Surgery
Department of Surgery, University of British Columbia, Vancouver, British Columbia
Supervisor: Dr RG Turnbull
Project: Development of guidelines to define maximum waiting times for definitive surgical treatment of various vascular conditions

June-Aug 1993





Rural Health Care Development in the Northern Areas of Pakistan
Aga Khan University and Health Services, Gilgit, Pakistan
Supervisor: Dr S Rasmussen
Project: Strategies to reduce infant mortality in underdeveloped areas of Northern Pakistan


Grant Support:

Agency Investigators Project Title Period of Support Amount

National Institutes of Health/NIDDK




Shapiro, AMJ (PI)
Anderson, CC (co-PI)
Nanji, S (Co-Investigator


ICOS-B7h in Islet Transplant Rejection and Autoimmunity



2003-2005




500,000 US (total)



Lifescan Inc.
(Johnson & Johnson)

Shapiro, AMJ (PI)
Nanji S (Co-Investigator)

Animal Model for LIving-Donor Islet Transplantation

2004-2005



80,000 Cdn (total)

Canadian Association of General Surgeons

Nanji S (PI)



Costimulatory Blockade and Tolerance Induction in Islet Transplantation

2002-2003



10,000 Cdn (total)

The Canadian Institutes of Health Research

Nanji S



Tolerance Induction in Experimental Islet Transplantation

2001-2004



Salary Stipend


The Alberta Heritage Foundation for Medical Research

Nanji S




Tolerance Induction in Experimental Islet Transplantation


2001-2004




Salary Stipend



 

Peer-Reviewed Research Presentations:

March 2009




Chemotherapy-Associated Liver Injury in Resections for Metastatic Colorectal Carcinoma: Vascular Injury, but not Steatohepatitis, is Associated with Type of Preoperative Chemotherapy
American Hepato-Pancreato-Biliary Association, Miami, Florida, USA

March 2005



Blockade of CD40 is an Effective Strategy in Prolonging Islet Allograft Survival
Canadian Society of Transplantation, Banff, Alberta

April 2004


Alterations in Immune Function During Spaceflight
Canadian Space Agency, Montreal, Quebec

Oct 2004


Medical and Surgical Challenges in Long Duration Spaceflight
Province Wide Rounds, Edmonton, Alberta

Sept 2004
May 2004




Combined Blockade of ICOS and CD40L Costimulation Induces Dominant Tolerance to Islet Allografts and Prevents Spontaneous Autoimmune Diabetes in NOD Mice
International Congress of the Transplantation Society, Vienna, Austria
Department of Surgery Resident Research Day, Edmonton, Alberta

May 2004
Feb 2004




A Role for Graft Site and Lymphatics in the Effectiveness of Costimulation Blockade-Based Strategies in Murine Models of Transplantation
American Transplant Congress, Boston, MA
Canadian Society of Transplantation, Montreal, Quebec

Feb 2004



Combination Therapy with CD40L mAb and Rapamycin Induces Robust Immunological Tolerance to Islet Allografts
Canadian Society of Transplantation, Montreal, Quebec

Sept, July, June 2003




Multiple Combination Therapies Involving Blockade of ICOS/B7RP-1 Costimulation Facilitate Long-Term Allograft Survival
Canadian Surgery Forum, Vancouver, British Columbia
International Pancreas and Islet Transplant Association, Dublin, Ireland
Department of Surgery Resident Research Day, Edmonton, Alberta

June, Mar and Mar 2003




Targeting the ICOS-B7h Pathway Synergizes with Rapamycin to Regulate Alloresponses in vivo
American Transplant Congress, Washington DC
International Cell Transplant Society, Atlanta, Georgia
The Canadian Society of Transplantation, Lake Louise, Alberta

Sept 2002, Sept 2002 and May 2002



Anti-ICOS Antibody and Sirolimus Leads to Prolonged Islet Allograft Surgival
The Canadian Society for Clinical Investigation, Ottawa, ON
Canadian Surgery Forum, London, ON
Department of Surgery, Resident Research Day, Edmonton, Alberta

April 2002 and Feb 2002


Islet Transplantation and Health-Related Quality of Life
American Transplant Congress, Washington, DC
Canadian Society of Transplantation, Montreal, Quebec

April 2002



Portal Venous Pressure Changes Following Sequential Islet Transplantation
American Transplant Congress, Washington, DC


Peer-Reviewed Publications:

Papers:

1. 





Ryan P, Nanji S, Pollett A, Moulton CA, Gallinger S, Guindi M. Chemotherapy-Induced Liver Injury in Metastatic Colorectal Cancer: Semi-Quantitative Histologic Analysis of 334 Resected Liver Specimens Shows Vascular Injury but not Steatohepatitis is Associated with Preoperative Chemotherapy. Journal of Clinical Oncology 2009 (submitted)

2.




Dubay DA, Kachura JR, Ho CS, Beecroft JR, Cheow PC, Vollmer CM, Ghanekar A, Guba M, Nanji S, Cattral MS, McGilvary ID, Kashfi A, Qiu K, Smirth RJ, Sherman M, Levy GA, Grant DR, Greig PD. Is Radiofrequency Ablation of Hepatocellular Carcinoma as a Bridge to Transplant Beneficial? Liver Transplantation 2009 (submitted)

3.



Luo B, Chan WFN, Lord SJ, Nanji S, Rajotte, Shapiro AMJ, Anderson CC. Diabetes Induces Rapid Suppression of Adaptive Immunity Followed by Homeostatic T Cell Proliferation. Scandinavian Journal of Immunology 2007;65(1):22-31

4.



 
Nanji SA, Hancock WW< Luo B, Schur CD, Pawlick RL, Zhu LF, Anderson CC, Shapiro AMJ, Costimulation Blockade of Both Inducible Costimulator and CD40 Ligand Induces Dominant Tolerance to Islet Allografts and PRevents Spontaneous Autoimmune Diabetes in the NOD Mouse. Diabetes 2006;55(1):27-33

5.

 
Nanji SA, Shapiro AMJ. Advances in Pancreatic Islet Transplantation in Humans. Diabetes, Obesity & Metabolism 2006;8(1):15-25

6.



Luo B, Nanji SA, Schur CD, Pawlick RL, Anderson CC, Shapiro AMJ, Robust Tolerance to Fully Allogeneic Islet Transplants Achieved by Chimerism with Minimal Conditioning. Transplantation 2005;80(3):370-7

7.

 
Nanji SA, Shapiro AMJ. Costimulation Blockade in Transplantation. European Journal of Hospital Pharmacy 2004;10(5):28-9

8.


Nanji SA, Shapiro AMJ. Islet Transplantation in Patients with Diabetes Mellitus: Choice of Immunosuppression. Biodrugs 2004;18(5):315-28

9.




Nanji SA, Hancock WW, Anderson CC, Adams AB, Luo B, Schur CD, Pawlick RL, Wong L, Coyle AJ, Larsen CP, Shapiro AMJ. Multiple Combination Therapies Involving Blockade of ICOS/B7RP-1 Costimulation Facilitate Long-Term Islet Allograft Survival. American Journal of Transplantation 2004;4(4):526-536

10.



Nanji SA, Hancock WW, Anderson CC, Zhu LF, Kneteman NM, Shapiro AMJ. Combination Therapy with Anti-ICOS and Cyclosporine Enhances Cardiac but not Islet Allograft Survival. Transplantation Proceedings 2003;35(7):2477-8

11.


Shapiro AMJ, Nanji SA, Lakey JRT. Clinical Islet Transplantation: Current and Future Directions Towards Tolerance. Immunological Reviews 2003;196:219-36

12.



Casey JJ, Lakey JRT, Ryan EA, Paty BW, Owen R, O'Kelly K, Nanji S, Rajotte RV, Korbutt GS, Bigam D, Kneteman NN, Shapiro AMJ. Portal Venous Pressure Changes Following Sequential Islet Transplantation. Transplantation 2002;74(7):913-15

13. 


 
Turnbull RG, Taylor DC, Hsiang YN, Salvian AJ, Nanji SA, O'Hanley G, Doyle DL, Fry PD. Assessment of Patient Waiting Times for Vascular Surgery. Canadian Journal of Surgery 2000;43(2):105-11

14.


Nanji SA, Mock CN, Gastric Rupture Resulting from Blunt Abdominal Trauma and Requiring Gastric Resection. Journal of Trauma 1999;47(2):410-12

Abstracts:

1.   



Ryan P, Nanji SA, Pollett A, Moore M, Moulton CA, Guindi M, Gallinger S. Use of Oxaliplatin and Irinotecan Prior to Hepatic Resection of Colorectal Cancer Metastases is not Associated with Chemotherapy-Associated Steatohepatitis (CASH) in a Clinic-Based Canadian Population. HPB 2009;11(S1):39

2.




Nanji SA, Anderson CC, Luo B, Hancock WW, Adams AB, Schur CD, Pawlick RL, Zhu LF, Kneteman NM, Shapiro AMJ. A Role for Graft Site and Lymphatics in the Effectiveness of Costimulation Blockade-Based Strategies in Murine Models of Transplantation. American Journal of Transplantation 2004;4(S8):510

3.




Nanji SA, Hancock WW, Anderson CC, Adams AB, Luo B, Schur CD, Pawlick RL, Wong L, Coyle AJ, Larsen CP, Shapiro AMJ. Targeting the ICOS-B7h Costimulatory Pathway Synergizes with Rapamycin to Regulate Alloresponses in Islet Transplantation. Cell Transplantation 2003;12(2)

4.




Nanji SA, Hancock WW, Anderson CC, Adams AB, Luo B, Schur CD, Pawlick RL, Wong L, Coyle AJ, Larsen CP, Shapiro AMJ. Targeting the ICOS-B7h Costimulatory Pathway Synergizes with Rapamycin to Regulate Alloresponses in Islet Transplantation. Transplantation 2003;76(4 Suppl):S19-68

5.




Nanji SA, Hancock WW, Anderson CC, Adams AB, Luo B, Schur CD, Pawlick RL, Wong L, Coyle AJ, Larsen CP, Shapiro AMJ. Targeting the ICOS-B7h Costimulatory Pathway Synergizes with Rapamycin to Regulate Alloresponses in Islet Transplantation. American Journal of Transplantation 2003;S5(3):291

6.



Casey JJ, Lakey JRT, Ryan EA, Paty BW, Owen R, O'Kelly K, Nanji S, et al. Portal Venous Pressure Changes Following Sequential Islet Transplantation. American Journal of Transplantation 2002;S3(2):228

7.



Johnson JA, Nanji SA, Supina A, LAkey, JRT, Ryan EA, Shapiro AMJ, Islet Transplantation and Health-Related Quality of Life: Results of an Initial Pilot Study. American Journal of Transplantation 2002;S3(2):229

Book Chapters:

1. 


Shapiro AMJ, Nanji SA. Progress in Islet Transplantation. Book Chapter in Stem Cells: From Bench to Bedside. Edited by Ariff Bongso and Eng Hin Lee. World Scientific Publishing 2005.